Basic Science and Alcoholism

Implications of endogenous opioids and dopamine in alcoholism: human and basic science studies.

We investigated the endogenous opioid system and its role in mediating the reinforcing effects of ethanol that lead to high ethanol consumption as a biochemical marker of an individual's vulnerability to excessive ethanol consumption. We performed studies using human subjects with [high risk (HR)] and without [low risk (LR)] a family history of alcoholism to supplement our studies with experime...

Basic Facts for Basic Science

Overall, this outstanding text should soon become recognized as the definitive reference for the diagnosis and management of ocular trauma. The tall, narrow shape of Basic Facts for Basic Science suggests that perhaps the author intended that it be put into the pocket of one's lab coat; perhaps not, but this book is certainly appropriate for the shelf of any laboratory and for the office of any...

How basic is basic science?

Some other possible conclusions come easily to mind. Perhaps, if we’re really concerned about students’ learning evidence-based medicine, then we should teach it more or better. On the other hand I am one of many who have joined the anti-EBM movement (Norman 1999). In my view, the fundamental irony remains that, even though it made the BMJ’s ‘‘Top 15 Medical Innovations of all Time’’ list in 20...

Basic Science

Basic science and public policy.

I would like to address my attention to the Cancer Program as seen by the basic science community, not so much in terms of dollars and cents but of the objectives; i.e., where and how the basic sciences should fit and what role they have been asked to play in the Program. I am not going to deal with specifics of appropriation from the NCI budget, nor with the scientific basis of cancer control....